September 18, 2021

Questions Childhood Vaccination

A few days before the start of the school year, two scientists, Pierre Sonigo and Jean-Marc Sabatier, express reservations.Recommendations for students to be vaccinated were interviewed by Dr. Jane Michelle Wendling *.

Pierre Sonigo (DR)
Pierre Sonigo (DR)
Jean-Marc Subatier (DR)
Jean-Marc Subatier (DR)

Pierre Songo, Former INSERM Research Director and Scientific Director – SEBIA.

Jean-Marc Sabatier, Research Director for CNRS and Dr. in Cell Biology and Microbiology, affiliated with the Institute of Neurophysiology (INP) at the University of Ox Marcel.

Are children better equipped to deal with the virus than others?

Pierre Sonigo- The corona virus COVID-19, which surrounds us, has been a major lack of communication while being the key to coherent reading of the situation. Cross-Immunity 2020, affected by these historical childhood viruses, is the perfect explanation for the miraculous protection of our children and young subjects during the emerging shock. These common viruses are gone from our minds, but they are only for young people who have been vaccinated before. Kills thousands of old or weak subjects from a very old childhood infection and every winter. Surprisingly, the spotlight has been put on the latest member of the family, SARS-COV2, as we were, and rightly so, with an incredibly devastating emergence.

Is there any reason to worry about the Delta variety of children?

PS We must keep our heads down and be calm. Anxiety-provoking and confusing communication is on the rise, while the evolutionary link between SARS-COV2 and its local cousins ​​has reached a form with a strong mucosal trapezium, highly contagious, low pathogenic potency: we delta With the wolf screaming, we completely ignore the other corona viruses that are all around us and that have very virological features. The difference was only due to the small exceptions of the older population, a difference that is well absorbed today.

SARS-COV2 is today. Local 5ᵉ corona virus.. Let us accept living with him as we did with his predecessors and very much hope that the coming autumn numbers will allow us to regain, in a “first life” Failure, some comfort and time to prepare for long-term precautions and rigorous research, out of emergencies

Are MRNA Vaccines Suitable for Adolescents?

Jean-Marc Sabatier Two mRNA vaccines (from Pfizer-Biotech and Modern) have been approved in France to vaccinate children and adolescents (ages 12 to 17). One dose of the comorbid vaccine (Pfizer Biotech) contains 30 micrograms of mRNA in lipid nanoparticles, while one dose of the spike vaccine (modern) contains 100 micrograms of mRNA.
In the context of a vaccination strategy for 12-17 year olds (which seems inappropriate to me given the almost non-non-lethality of SARS-CoV-2 in this age group, and the fact that People who get vaccinated also have the ability to transmit the virus.), These foods, which are initially designed for adults, should be adapted, especially to those with a lower average body weight and a stronger immune response. in view of. For the latter, relatively high doses of the vaccine can be harmful and cause more side effects, without a better immune response to the virus. For example, it appears that the spike vaccine vaccine (about 3 times more common than the comorbid vaccine in mRNA) is associated with a higher incidence of myocarditis.

Do myocarditis cases affect young people more after vaccination?

JMS– In fact, cases of acute myocarditis (although very rare), but also pericarditis, are associated with the administration of the mRNA vaccine, especially in young men (14-29 years old). It is an inflammation of the heart muscle. The condition usually appears within three to fourteen days, and mainly after the second dose of the vaccine: it requires adjuvant treatment with anti-inflammatory drugs. Myocarditis is characterized by palpitations or arrhythmias, shortness of breath and / or sudden and temporary chest pain.

What are your specifications?

JMS – In my opinion, myocarditis, in this case, is a possible side effect associated with the increased activity of the renin-angiotensin system (RAS) of myocardial cells by vaccine spike protein. The proinflammatory AT1R receptor of RAS is directly responsible. RAS varies between children, adolescents, adults and the elderly. These additional differences may explain the increased susceptibility of myocarditis in vaccinated adolescents.

Can these complications, which are found in young men, be explained by the hormonal factor?

JMS The low prevalence of myocarditis in young women may be due to the cardiovascular protection provided by estrogen (female hormones). Estrogen has been shown to protect against heart disease in women. Estrogen lowers the levels of ACE2 receptors (ACE2 = “angiotensin converting enzyme 2” which belongs to the RAS and is coded by the X sex chromosome). This is the receptor that binds the spike protein (viral or vaccine) to the heart.

Can vitamin D deficiency increase the side effects of the vaccine or affect its effectiveness?

JMS Yes, because of the ability of the vaccine spike protein, developed from the mRNA vaccine, to bind to its ACE2 receptor and to make RAS more active, as shown by the ability of SARS-V-2 ۔ Vitamin D is able to slow down the excess activity of RAS by stopping the production of rennet and will therefore counteract the onset of major side effects. A person with vitamin D deficiency and vitamin D deficiency will not be “armed” to prevent the side effects of the vaccine. That is why it is very important to have a good state of vitamin D (40-60 ng calcidiol per ml) before any vaccination, which allows the immune system to function better.

Is vitamin D deficiency possible at age 18? How do you know And what should you do if you decide to get vaccinated?

JMS Vitamin D deficiency (12-30ng calcidiol per ml of blood) or deficiency regardless of age (<12 ng calcidiol / mL) ہونا ممکن ہے۔ مطالعے سے پتہ چلتا ہے کہ فرانسیسی آبادی کی اکثریت میں وٹامن ڈی کی کمی ہے۔ خوراک عام طور پر ناکافی ہے. لہذا یہ مشورہ دیا جاتا ہے کہ خوراک کے لیے اپنے ڈاکٹر سے رابطہ کریں اور اگر لیول بہت کم ہے تو اطمینان بخش سطح (> Proceed with the supplement to reach 40 ng calcidiol / ml).

* Jean-Michel Wendling, an occupational health prevention specialist in Strasbourg, is a scientific adviser at infodujour.fr.

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